Drug Safety 2007; 30 (7): 623-625

نویسنده

  • Andrew Bate
چکیده

A Bayesian confidence propagation neural network (BCPNN)-based technique Abstract has been in routine use for data mining the 3 million suspected adverse drug reactions (ADRs) in the WHO database of suspected ADRs of as part of the signal-detection process since 1998. Data mining is used to enhance the early detection of previously unknown possible drug-ADR relationships, by highlighting combinations that stand out quantitatively for clinical review. Now-established signals prospectively detected from routine data mining include topiramate associated glaucoma, and the SSRIs with neonatal withdrawal syndrome. Recent advances in the method and its use will be discussed: (i) the recurrent neural network approach used to analyse cyclo-oxygenase 2 inhibitor data, isolating patterns for both rofecoxib and celecoxib; (ii) the use of data-mining methods to improve data quality, especially the detection of duplicate reports; and (iii) the application of BCPNN to the 2 million patient-record IMS Disease Analyzer.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Lipid Intermediates in the Biosynthesis of Bacterial Peptidoglycan

INTRODUCTION .......................................................................................................................................................620 DETECTION OF THE LIPID INTERMEDIATES IN CELL-FREE SYSTEMS ..............................................621 DETECTION OF THE LIPID INTERMEDIATES IN INTACT CELLS AND THEIR POOL LEVELS ......621 ISOLATION AND PURIFICATION OF THE LI...

متن کامل

ChApTeR 40 Zebra Mussel Impacts on Unionids A Synthesis of Trends in North America and Europe

............................................................................................................................................................................... 623 Introduction .......................................................................................................................................................................... 624 Case Study Sites ...............

متن کامل

Continuous positive airway pressure delivered by oronasal mask may not be effective for obstructive sleep apnoea.

REFERENCES 1 Sotgiu G, Ferrara G, Matteelli A, et al. Epidemiology and clinical management of XDR-TB: a systematic review by TBNET. Eur Respir J 2009; 33: 871–881. 2 Ködmön C, Hollo V, Huitric E, et al. Multidrugand extensively drug-resistant tuberculosis: a persistent problem in the European Union European Union and European Economic Area. Eurosurveillance 2010; 15: 19519. 3 Migliori GB, Besoz...

متن کامل

Validation of Instruments for Assessing Drug Safety Management During the Conduction of Clinical Trials

Background The management of drug safety with the collection of reliable safety data during the conduction of clinical trials conduct is essential for the registry and marketing of products. The systematic evaluation of this process, based on objective measures, requires the application of quality instruments. This study was aimed to design and validate eight instruments through the components ...

متن کامل

Infinitesimal Presentations of the Torelli Groups

Contents 1. Introduction 597 2. Braid groups in positive genus 601 3. Relative completion of mapping class groups 603 4. Mixed Hodge structures on Torelli groups 608 5. Review of continuous cohomology 613 6. Remarks on the representations of sp g 616 7. Continuous cohomology of Torelli groups 618 8. The lower central series quotients of a surface group 621 9. The action of t 1 g on p g 623 10. ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2007